Application of hydroxyapatite nanoparticles in tumor-associated bone segmental defect

Hydroxyapatite (HA) has been widely applied in bone repair because of its superior biocompatibility. Recently, a proliferation-suppressive effect of HA nanoparticles (n-HA) against various cancer cells was reported. This study was aimed at assessing the translational value of n-HA both as a bone-regenerating material and as an antitumor agent. Inhibition of tumor growth, prevention of metastasis, and enhancement of the survival rate of tumor-bearing rabbits treated with n-HA were demonstrated. Activated mitochondrial-dependent apoptosis in vivo was confirmed, and we observed that a stimulated immune response was involved in the n-HA–induced antitumor effect. A porous titanium scaffold loaded with n-HA was fabricated and implanted into a critical-sized segmental bone defect in a rabbit tumor model. The n-HA–releasing scaffold not only showed a prominent effect in suppressing tumor growth and osteolytic lesion but also promoted bone regeneration. These findings provide a rationale for using n-HA in tumor-associated bone segmental defects. Bone tumors and cancer metastases to the bone pose serious threats to human health. In the United States, approximately 2500 new cases of primar...

How to Know When to Change Spray Booth Filters | Products Finishing

When it comes to determining when to change your spray booth filters, Trey Peavy from Col-Met Engineered Finishing Solutions says to first differentiate between intake filters and exhaust filters. A: When it comes to determining when to change your spray booth filters, first we have to differentiate between intake filters and exhaust filters. Intake filters are located where the outside or shop air is introduced to the spray booth working environment. These filters work to ensure that the air introduced into the spray booth is free from debris, which can cause defects in your coatings. Exhaust filters are possibly located in several different locations, depending on the design and construction of your spray booth. The primary function of these filters is to capture overspray from the booth working environment and prevent harmful and hazardous particulates from being exhausted into the atmosphere by the booth exhaust fans. The function of both filter types is paramount to the spray booth functioning properly and ensuring the best possible coating finish. Spray booths are designed to meet National Standards, such as OSHA and the NFPA. When filter maintenance is neglected, the perf...

12 Self-Care Tips To Remember When You’re Working From Home

Everyone has their own method when it comes to working from home, but one of the most important things to remember when working remotely is to create a distinction between your work and personal life. Self-care is just as vital in the office as it is when you’re working from home. It can be easy to slip into bad habits when spending all day indoors, but in order to work efficiently — and to take good care of your health — there are a few things the experts recommend you do. Whether it’s taking a proper lunch break, setting up a desk area, heading out for a run or ensuring your working environment is kept clean, there are many simple things to do to make working at home productive and enjoyable. Planning to work remotely soon? Business Insider have revealed the top self-care tips to remember when working from home. Keep reading for practical ways you can easily adopt in your own daily routine… When you’re not in the office, it’s easy to slip into habits such as working late into the evening. In order to maintain a healthy balance between work and play, put clear boundaries in place so that there is a distinction between the hours you need to work an...

Double-sided tape for tissues could replace surgical sutures

New adhesive that binds wet surfaces within seconds could be used to heal wounds or implant medical devices. Watch Video Inspired by a sticky substance that spiders use to catch their prey, MIT engineers have designed a double-sided tape that can rapidly seal tissues together. In tests in rats and pig tissues, the researchers showed that their new tape can tightly bind tissues such as the lungs and intestines within just five seconds. They hope that this tape could eventually be used in place of surgical sutures, which don’t work well in all tissues and can cause complications in some patients. “There are over 230 million major surgeries all around the world per year, and many of them require sutures to close the wound, which can actually cause stress on the tissues and can cause infections, pain, and scars. We are proposing a fundamentally different approach to sealing tissue,” says Xuanhe Zhao, an associate professor of mechanical engineering and of civil and environmental engineering at MIT and the senior author of the study. The double-sided tape can also be used to attach implantable medical devices to tissues, including the heart, the researchers showed. In addition, it wo...

100年以上の歴史ある洋食店『ランチョン』のエビフライ / 東京芸術大学の学生に愛される味 | ガジェット通信 GetNews

明治24年に創業した洋食レストラン『ランチョン』をご存知だろうか? 東京芸術大学の学生に愛され続けているレストランとしても有名で、店名の由来も芸大生が深く関連している。 ・地域住民に愛され続ける味 もともと店名がない洋食屋として開業したため、ずっと「洋食屋」と呼ばれて地域住民に愛され続けていた。しかし、常連の音楽大学(現在の芸大)の学生から「店名がないと不便だしわかりにくいよね……」という声があがり、学生が考えた『ランチョン』になったという。 ・エビフライを見て納得 ここの名物はエビフライ。実はほかにも名物料理があるのだか、はじめて『ランチョン』にきてエビフライを注文しないのはモグリだという。正直、2200円という価格に驚かされるが、テーブルにやってきたエビフライを見て納得。 ・ヴェールに包まれたプリプリの極太エビ スケールのデカさに負けた。これならば2200円は安い。3000~4000円してもおかしくないレベルである。あまりにも大きすぎるので、フォークで切って、2回目の驚きが訪れた。ザクザクでクリスピーな分厚い衣、そしてヴェールに包まれたプリプリの極太エビ。 ・これがまたビールに合うのだ 食べる前からその魅力にとりつかれてしまったが、食べればその魅力から逃れることはできない。砕ける衣、はじけるエビ、そして自家製タルタルソースの爽やかさ、どれもパーフェクトに近い、至福の味。これがまたビールに合うのだ。ちょっと...

Everything you need to know about sustainable fragrances

There’s no glossing over it – the beauty industry is one of the biggest culprits in contributing waste to landfills. From the use of facial wipes (one of the worst offenders) to excessive packaging, it’s high time we reconsider our beauty purchases, and this applies to fragrance as well. Thierry Mugler’s refillable perfume scheme – The Source – was a novel idea 27 years ago. Today, other brands have caught on, though we do wonder when this waste-minimising approach will be standard. But, it’s not simply refills that give perfume a sustainability badge of honour. Here, with the help of industry experts, we break down all you need to know when it comes to getting greener with your scent buys. There’s no legal definition, so try thinking about your perfume as a whole, instead of just the finished product. Ethically-sourced ingredients, eco-conscious packaging, and creating a social impact are all factors that contribute to a fragrance’s sustainability credentials. “Often people will talk about provenance and that the ingredients are sourced in a way that does not harm the environment,” says Amy Christiansen Si-Ahmed, founder of Sana Jardin. “We a...

33 Things That Seriously Upgrade Your Bathroom For Less Than $20 On Amazon

It’s the one room of the house where you spend a lot of time but expend hardly any gray matter thinking about: Your bathroom. Isn’t it about time you give it a little TLC? Start with these upgrades from Amazon for under $20 that all deliver major oomph. Granted, I have moved on from college dorm-style bleak, but with the tiny bathrooms I’ve had to contend with over the years, it wasn’t until I started researching this article and a few others that I realized how even a little spend could make a big difference — even when your space is practically closet-sized. The moral of the story here is that it’s neither your wallet’s size nor your bathroom’s size that makes the difference…it’s the amount of time you spend choosing the right accessories for your upgrade that really drives the payoff when you’re sprucing up a bathroom. But who has that kind of time?, you ask. Hey, that’s why I’m here for you! This list is chock full of ideas that I’ve researched so you don’t have to. Whether you’re looking for organization ideas to get all your stuff off your bathroom counters so you can have a calm, pea...

Netgear Nighthawk AX8 8-Stream Wi-Fi 6 Router (RAX80) Review

The Netgear Nighthawk AX8 RAX80 is a Wi-Fi 6 router that offers speedy throughput and excellent file-transfer performance. Netgear’s Nighthawk AX8 8-Stream Wi-Fi 6 Router (RAX80) joins the Asus RT-AX88U as the first 802.11ax routers to hit our labs. Shaped like a futuristic starship, the RAX80 boasts an impressive feature set that includes five gigabit LAN ports, link aggregation, a powerful quad-core processor, and of course, 802.11ax wireless technology, also known as Wi-Fi 6. At $399.99, the RAX80 doesn’t come cheap, but it turned in some impressive scores on our throughput tests, and its file-transfer performance is top-notch. However, you don’t get the robust game-friendly QoS options and anti-malware tools that you get with the Asus RT-AX88U, and as is the case with the RT-AX88U, you’ll have to wait for Wi-Fi 6 clients to hit the market to take full advantage of all that the RAX80 has to offer. Wi-Fi 6, also known as 802.11ax or High Efficiency (HE) Wireless, is the latest Wi-Fi protocol. An evolution of 802.11ac technology, 802.11ax promises increased throughput speeds (up to 4.8Gbps), less network congestion, greater client capacity, and better ra...